Syphilis Tests

Microhemagglutination assay (MHA-TP), (Syphilis Test), Rapid Plasma Reagin (RPR) Test, (Syphilis Test), Venereal Disease Research Laboratory (VDRL) Test, (Syphilis Test)

Risks

Sore or skin sample

There is very little risk of complications from having a sample taken from an open sore (chancre), skin rash, or mucous membrane.

Blood sample

There is very little chance of a problem from having blood sample taken from a vein.

• You may get a small bruise at the site. You can lower the chance of bruising by keeping pressure on the site for several minutes.
• In rare cases, the vein may become swollen after the blood sample is taken. This problem is called phlebitis. A warm compress can be used several times a day to treat this.
• Ongoing bleeding can be a problem for people with bleeding disorders. Aspirin, warfarin (Coumadin), and other blood-thinning medicines can make bleeding more likely. If you have bleeding or clotting problems, or if you take blood-thinning medicine, tell your doctor before your blood sample is taken.

Spinal fluid sample

There is little risk associated with having a lumbar puncture to obtain a spinal fluid sample for syphilis testing. For more information, see the medical test Lumbar Puncture.

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Author:	Kathe Gallagher, MSW	Last Updated: October 2, 2007
Medical Review:	Kathleen Romito, MD - Family Medicine Jeanne Marrazzo, MD, MPH - Infectious Disease
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