Alemtuzumab

Examples

Generic Name	Brand Name
alemtuzumab	Campath, MabCampath

Alemtuzumab is given intravenously or as a shot under the skin.

How It Works

Alemtuzumab is a monoclonal antibody that attaches itself to a protein called CD52. This protein is found on the surface of some cancer cells, including most chronic lymphocytic leukemia (CLL) cells. It helps your immune system see the cancer cell as something that needs to be destroyed.

Why It Is Used

Alemtuzumab is used to treat CLL that has come back after remission or does not respond to other chemotherapy. It may also be combined with other drugs when first treating CLL. Alemtuzumab is sometimes used in clinical trials to treat other types of leukemia.

How Well It Works

Alemtuzumab is an effective treatment for about 40% of people with CLL that has not improved with other chemotherapy drugs, such as cyclophosphamide or fludarabine.

Alemtuzumab is effective for about 80% of people with CLL who have symptoms but have not had other chemotherapy.¹Clinical trials are ongoing.

Side Effects

Common side effects include:

• A weakened immune system, which increases your risk of infection.
• Low blood counts, which may increase your risk of infection or bleeding.
• Skin rashes and itching.
• Swelling of the tongue or in the throat (angioedema) caused by an allergic reaction.
• Wheezing, coughing, and shortness of breath.
• Fever and chills.
• Dizziness.
• Headaches.
• Muscle aches.
• Fatigue.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

Alemtuzumab should be used only under the supervision of a medical oncologist or hematologist.

Alemtuzumab can cause birth defects. Do not use this drug if you are pregnant or wish to become pregnant or to father a child while you are taking it.

Do not use alemtuzumab if you are breast-feeding. The drug can pass into your breast milk.

Alemtuzumab can interact with many other drugs. Be sure your doctor knows what prescription and over-the-counter drugs you are taking.

Use alemtuzumab with caution if you have heart disease. The drug may make existing heart problems worse.

This drug has been studied for use only in adults. Its safety and effectiveness have not been established in children.

Complete the new medication information form (PDF) (What is a PDF document?) to help you understand this medication.

Author:	Kathe Gallagher, MSW	Last Updated November 30, 2006
Medical Review:	Caroline S. Rhoads, MD - Internal Medicine Joseph O'Donnell, MD - Hematology
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